Some time ago rumors abounded that you should not use a Microsoft registery cleaner too much and that it could hurt your pc more than the good it does. Today’s registry cleaners are not a problem, and not using them can cause more damage than good. The recommended use of a registry cleaner is between once a week or once a month. Unless your computer is invaded with spyware, in those cases the registry cleaner should be used right after the virus remover is used.